liraglutide chemical structure liraglutide chemical name
Sep 9, 2026 6:35 AM
# Exploring the Liraglut This is consistent with the fibril formation observed for liraglutide 81, 346 which is identical in structure apart from C-terminal amidation. ide Chemical Structure: A Personal Technical Review
For those interested in the biochemical composition of synthetic peptides, understanding the liraglutide chemical structure is a fascinating dive into protein engineering. As an enthusiast who keeps a detailed log of peptide structures for comparative research, I have found that studying molecules at this level of granularity provides clarity on why specific modifications dictate such distinct molecular behaviors.
When I first analyzed the liraglutide chemical structure, the precision of its assembly was immediately apparent. Liraglutide is essentially a synthetic analog of the naturally occurring human gluc KEGG DRUG: Liraglutide - GenomeNet agon-like peptide-1 (GLP-1). However, it is the specific modifications to the backbone that set it apart.
With a total of thirty-one (31) amino acids, the liraglutide amino acid sequence is derived directly from human GLP-1(7-37), bu This in-depth guide has provided a comprehensive overview of Liraglutide's molecular structure, its binding affinity to the GLP-1 … t with a critical substitution: the lysine residue at position 34 is replaced by Primary structure of liraglutide (shaded residues indicate differences arginine, and the lysine at position 27 is modified with a palmitoyl fatty acid chain via a glutamic acid spacer. This C16 fatty acid chain (palmitic acid) is the “secret sauce” that allows the molecule to bind to albumin, significantly extending its half-life compared to the native, rapidly degraded GLP-1 hormone.
Technical Data and Specifications
For researchers, defining the liraglutide molecular weight is essential for molar calculations. It features a molecular formula of C₁₇₂H₂₆₅N₄₃O₅₁, giving it a calculated molecular weight of approximately 3751.2 g/mol. When looking at chemical documentation, you may often see the liraglutide chemical name: *N-ε-(γ-L-glutamoyl(N-α-hexadecanoyl))-Lys26, Arg34-GLP-1(7-37)*.
If you are cataloging this for a lab database, the liraglutide SMILES string—a canonical representation used to encode the structure—is often required for 3D modeling software. Accessing this via open-source repositories like PubChem (CID 16134956) or ChemSpider has helped me visualize the interaction between the fatty acid tail and the peptide backbone.
Key Considerations for Handling
In my experience analyzing peptides, liraglutide solubility in water and buffer solutions is a classic topic of discussion. Due to the attached lipophilic C16 chain, it behaves differently than smaller, purely hydrophilic peptides. It is generally handled in an alkaline environment (often adjusted with specific buffers to reach a pH of 8.0–9.0) to achieve optimal solubility for high-purity applications.
Many ask, is liraglutide a biologic? Yes, given that it is a recombinant DNA-derived peptide analog, it falls under the classification of a biologic drug product. It is distinct from small-molecule chemical entities because of its complex, folded tertiary structure, often studied in X-ray crystallography or NMR models under PDB entries like 4APD.
Observations on Its Innovation
The liraglutide innovator (Novo Nordisk) fundamentally changed the landscape of peptide therapy by demonstrating that a peptide could be modified to resist standard enzymatic degradation (specifically by DPP-4). By observing the comparison diagrams in research literature, you can visually distinguish the "shaded" residues—the specific modifications that prevent the peptide from being cleared too quickly from a system.
Summary of Specifications
* Molecular Formula: C₁₇₂H₂₆₅N₄₃O₅₁
* Length: 31 amino acids
* Key Modification: C16 fatty acid chain at Lys26
* CAS Number: 204656-20-2
* Primary Structural Feature: Alpha-helical conformation stabilized by the glutamic acid spacer.
Understanding the internal symmetry of such a molecule reinforces why quality control in chemical manufacturing i PDB-101: Diabetes Mellitus: Diabetes Mellitus: undefined: Liraglutide s paramount. Whether you are using this information for theoretical modeling or building a library of peptide analogs, the n (a) Liraglutide primary structure; 97% amino acid - ResearchGate uances of the liraglutide che Liraglutide structure mimics natural GLP-1 effectively agonizing GLP-1R to achieve desired metabolic outcomes. Additionally … mical structure serve as a premier example of how molecular engineering can optimize peptide functionality.
# Exploring the Liraglut This is consistent with the fibril formation observed for liraglutide 81, 346 which is identical in structure apart from C-terminal amidation. ide Chemical Structure: A Personal Technical Review
For those interested in the biochemical composition of synthetic peptides, understanding the liraglutide chemical structure is a fascinating dive into protein engineering. As an enthusiast who keeps a detailed log of peptide structures for comparative research, I have found that studying molecules at this level of granularity provides clarity on why specific modifications dictate such distinct molecular behaviors.
When I first analyzed the liraglutide chemical structure, the precision of its assembly was immediately apparent. Liraglutide is essentially a synthetic analog of the naturally occurring human gluc KEGG DRUG: Liraglutide - GenomeNet agon-like peptide-1 (GLP-1). However, it is the specific modifications to the backbone that set it apart.
With a total of thirty-one (31) amino acids, the liraglutide amino acid sequence is derived directly from human GLP-1(7-37), bu This in-depth guide has provided a comprehensive overview of Liraglutide's molecular structure, its binding affinity to the GLP-1 … t with a critical substitution: the lysine residue at position 34 is replaced by Primary structure of liraglutide (shaded residues indicate differences arginine, and the lysine at position 27 is modified with a palmitoyl fatty acid chain via a glutamic acid spacer. This C16 fatty acid chain (palmitic acid) is the “secret sauce” that allows the molecule to bind to albumin, significantly extending its half-life compared to the native, rapidly degraded GLP-1 hormone.
Technical Data and Specifications
For researchers, defining the liraglutide molecular weight is essential for molar calculations. It features a molecular formula of C₁₇₂H₂₆₅N₄₃O₅₁, giving it a calculated molecular weight of approximately 3751.2 g/mol. When looking at chemical documentation, you may often see the liraglutide chemical name: *N-ε-(γ-L-glutamoyl(N-α-hexadecanoyl))-Lys26, Arg34-GLP-1(7-37)*.
If you are cataloging this for a lab database, the liraglutide SMILES string—a canonical representation used to encode the structure—is often required for 3D modeling software. Accessing this via open-source repositories like PubChem (CID 16134956) or ChemSpider has helped me visualize the interaction between the fatty acid tail and the peptide backbone.
Key Considerations for Handling
In my experience analyzing peptides, liraglutide solubility in water and buffer solutions is a classic topic of discussion. Due to the attached lipophilic C16 chain, it behaves differently than smaller, purely hydrophilic peptides. It is generally handled in an alkaline environment (often adjusted with specific buffers to reach a pH of 8.0–9.0) to achieve optimal solubility for high-purity applications.
Many ask, is liraglutide a biologic? Yes, given that it is a recombinant DNA-derived peptide analog, it falls under the classification of a biologic drug product. It is distinct from small-molecule chemical entities because of its complex, folded tertiary structure, often studied in X-ray crystallography or NMR models under PDB entries like 4APD.
Observations on Its Innovation
The liraglutide innovator (Novo Nordisk) fundamentally changed the landscape of peptide therapy by demonstrating that a peptide could be modified to resist standard enzymatic degradation (specifically by DPP-4). By observing the comparison diagrams in research literature, you can visually distinguish the "shaded" residues—the specific modifications that prevent the peptide from being cleared too quickly from a system.
Summary of Specifications
* Molecular Formula: C₁₇₂H₂₆₅N₄₃O₅₁
* Length: 31 amino acids
* Key Modification: C16 fatty acid chain at Lys26
* CAS Number: 204656-20-2
* Primary Structural Feature: Alpha-helical conformation stabilized by the glutamic acid spacer.
Understanding the internal symmetry of such a molecule reinforces why quality control in chemical manufacturing i PDB-101: Diabetes Mellitus: Diabetes Mellitus: undefined: Liraglutide s paramount. Whether you are using this information for theoretical modeling or building a library of peptide analogs, the n (a) Liraglutide primary structure; 97% amino acid - ResearchGate uances of the liraglutide che Liraglutide structure mimics natural GLP-1 effectively agonizing GLP-1R to achieve desired metabolic outcomes. Additionally … mical structure serve as a premier example of how molecular engineering can optimize peptide functionality.